Endocrine Abstracts

Background: Hypothyroidism due to autoimmune thyroiditis leads to atherogenic lipid profile and metabolic changes. The formation of advanced glycation end products (AGEs) increases with hyperglycemia, hyperlipidemia and oxidative stress. Degradation of AGEs after AGEs-receptor 1-mediated intracellular uptake and renal clearance of soluble AGEs generated by certain cells like macrophages play a crucial role in the decrement of circulating AGEs level. Chemerin is an adipokine pr...

Background: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. Enhanced FGF21 production in diabetes and obesity reduces the level of LDL-C and triglycerides by suppression of hepatic SREBP-2. Hypothyroidism has also been shown to have unfavorable effects on atherogenesis and dyslipidemia. To date, the association of lipid p...

Background: The renin-angiotensin-aldosterone system (RAS) constitutes a key hormonal system in the physiological and pathological regulation of blood pressure. In effort to understand complex and multifunctional aspects of this system, current biochemical approaches target to characterize and define its various components with angiotensin II being in the mainstream.Objective: The aim of this study was to evaluate concentrations of angiotensin II in hype...

In secondary adrenal insufficiency (SAI), the Synacthen test can give a false negative result. If disease is strongly suspected, an insulin hypoglycaemia test or Metyrapone (Metopirone) test should be carried out. Insulin test could be hazardous for patients with adrenal insufficiency (due to high risk of severe hypoglycaemia), so in our clinic we use overnight single-dose Metyrapone test. Although this test is easy to perform, measurement of 11-deoxycortisol concentration is ...

Introduction: Patients with connective tissue diseases are susceptible to the occurrence of side-effects of long term treatment with low-dose glucocorticoids as these medications often cannot be withdrawn due to exacerbation of the underlying disease. The new-onset of glucose metabolism impairment is not considered common in patients treated with low-dose glucocorticoids and the risk factors are thought to be the same as in general population: increasing age, obesity or family...

Introduction: Observed increasing frequencies of asymptomatic or oligosymptomatic PHP cases may increase the rate of false negative imaging results.Aim: To determine the level of PTH and calcium at which an enlarged parathyroid gland can be detected by parathyroid SPECT/CT.Material and methods: A retrospective analysis of 117 patients diagnosed with PHP (100 females and 17 males, aged 16–88 years) was performed. In each patien...

Background: Diabetes mellitus is a lifelong chronic disease with higher risk of mortality and morbidityObjective: To study the risk factors of death in hospitalized diabetic patientsMethods: Data obtained from the database of the National Health Fund (NHF), a public organization financing medical procedures in Poland regarded 958305 hospitalizations of adult (≥18 years old) patients with diabetes in 2014 year. Logistic regres...

Context: The cyclical effects of hormones during the menstrual cycle (MC) are responsible for driving ovulation. The information about roles of adipokines within the scope of MC are not definite. Leptin plays a role in sexual function and regulating the onset of puberty. Thin girls often fail to ovulate or release an egg from an ovary during menstruation cycles. Leptin also acts on specific receptors in the hypothalamus to inhibit appetite. Levels of leptin are increased in wo...

Malignant transformation of the thyroid follicular cell in nodular goiter (NG) can lead to development of follicular adenoma (FA) or progression into: papillary thyroid carcinoma (PTC) or thyroid follicular cancer (FTC). Distinguishing follicular cell-derived thyroid tumors (FCDT) from NG on the molecular level can be especially helpful for underdetermined cytology (Bethesda III–IV) or FNAB with ‘follicular neoplasm’.Aim: Comparison of exp...

Background: Irisin is an adipokine/myokine which could be connected with insulin sensitivity. Polycystic ovary syndrome (PCOS) is characterized by oligo- or anovulation, polycystic ovary, hyperandrogenism and insulin resistance.Objective: The aim of the present study was to determine the relationship between serum irisin concentration and insulin sensitivity (Mffm) as well as the effect of insulin infusion on circulating irisin levels in PCOS ...